CALCIUM-ANTAGONISTS AND VASODILATATION

被引：74

作者：

GODFRAIND, T

机构：

[1] Laboratoire de Pharmacologie, Université Catholique de Louvain, UCL 5410, 1200 Brussels

来源：

PHARMACOLOGY & THERAPEUTICS | 1994年 / 64卷 / 01期

关键词：

CALCIUM ANTAGONISTS; CALCIUM-CHANNEL BLOCKERS; CALCIUM CHANNELS PHARMACOLOGY; CLASSIFICATION OF CALCIUM ANTAGONISTS; CALCIUM ANTAGONISTS AND HYPERTENSION; TISSUE SELECTIVITY OF CALCIUM ANTAGONISTS;

D O I：

10.1016/0163-7258(94)90033-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Calcium antagonists comprise a diverse group of chemically unrelated agents that interact with voltage-operated calcium channels (L-type) and thereby inhibit smooth muscle contractility. They are used to treat several major cardiovascular disorders, including hypertension and angina pectoris; they are also studied in congestive heart failure and in atherosclerosis. The current view is that their therapeutic action is related to vasodilatation. This view is an oversimplification, as will be shown in this review. It will also be illustrated that all calcium antagonists are not identical pharmacological agents.

引用

页码：37 / 75

页数：39

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