SYNTHESIS AND ANTIHERPETIC ACTIVITY OF (S)-9-[2,3-DIHYDROXY-1-PROPOXY)METHYL]GUANINE, (R)-9-[2,3-DIHYDROXY-1-PROPOXY)METHYL]GUANINE, AND (+/-)-9-[(2,3-DIHYDROXY-1-PROPOXY)METHYL]GUANINE, LINEAR ISOMERS OF 2'-NOR-2'-DEOXYGUANOSINE

被引：86

作者：

ASHTON, WT ^{[1
]}

CANNING, LF ^{[1
]}

REYNOLDS, GF ^{[1
]}

TOLMAN, RL ^{[1
]}

KARKAS, JD ^{[1
]}

LIOU, R ^{[1
]}

DAVIES, MEM ^{[1
]}

DEWITT, CM ^{[1
]}

PERRY, HC ^{[1
]}

FIELD, AK ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS,W POINT,PA 19486

来源：

关键词：

D O I：

10.1021/jm00145a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：926 / 933

页数：8

共 27 条

[1] ACTIVATION BY THYMIDINE KINASE AND POTENT ANTIHERPETIC ACTIVITY OF 2'-NOR-2'-DEOXYGUANOSINE (2'NDG)
ASHTON, WT
KARKAS, JD
FIELD, AK
TOLMAN, RL
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 108 (04) : 1716 - 1721
[2] BAER E, 1952, BIOCHEM PREPARAT, V2, P31
[3] SYNTHESIS OF I-O-BETA-D-GALACTOFURANOSYL-D-GLYCERITOL
BEVING, HFG
BOREN, HB
GAREGG, PJ
[J]. ACTA CHEMICA SCANDINAVICA, 1967, 21 (08): : 2083 - &
[4] CHENG YC, 1976, J BIOL CHEM, V251, P2605
[5] DAVIES MEM, 1984, ANTIMICROB AGENTS CH, V25, P238, DOI 10.1128/AAC.25.2.238
[6] MULTIPLE RANGE AND MULTIPLE F TESTS
DUNCAN, DB
[J]. BIOMETRICS, 1955, 11 (01) : 1 - 42
[7] AN IMPROVED METHOD FOR THE PREPARATION OF 1,2-ISOPROPYLIDENE-SN-GLYCEROL
EIBL, H
[J]. CHEMISTRY AND PHYSICS OF LIPIDS, 1981, 28 (01) : 1 - 5
[8] EIBL H, 1970, LIEBIGS ANN CHEM, V738, P161
[9] SELECTIVITY OF ACTION OF AN ANTI-HERPETIC AGENT, 9-(2-HYDROXYETHOXYMETHYL)GUANINE
ELION, GB
FURMAN, PA
FYFE, JA
DEMIRANDA, P
BEAUCHAMP, L
SCHAEFFER, HJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5716 - 5720
[10] 9-([2-HYDROXY-1-(HYDROXYMETHYL)ETHOXY]METHYL)GUANINE - A SELECTIVE INHIBITOR OF HERPES GROUP VIRUS-REPLICATION
FIELD, AK
DAVIES, ME
DEWITT, C
PERRY, HC
LIOU, R
GERMERSHAUSEN, J
KARKAS, JD
ASHTON, WT
JOHNSTON, DBR
TOLMAN, RL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13): : 4139 - 4143