INTERACTION OF SUBSTANCE-P, COMPOUND-48/80 AND MASTOPARAN WITH THE ALPHA-SUBUNIT C-TERMINUS OF G-PROTEIN

被引：176

作者：

MOUSLI, M

BRONNER, C

BOCKAERT, J

ROUOT, B

LANDRY, Y

机构：

[1] UNIV STRASBOURG 1,NEUROIMMUNOPHARMACOL LAB,F-67070 STRASBOURG,FRANCE

[2] CTR PHARMACOL ENDOCRINOL,CNRS,INSERM,MONTPELLIER,FRANCE

来源：

IMMUNOLOGY LETTERS | 1990年 / 25卷 / 04期

关键词：

Antibody; Compound; 48; 80; G proteins; Mastoparan; Pertussis toxin; Substance P;

D O I：

10.1016/0165-2478(90)90207-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pretreatment of purified calf brain G proteins with activated pertussis toxin or antibodies raised against the C-terminus of their α subunits prevented the increase in GTPase activity induced by substance P, compound 48 80 and mastoparan. These results suggest that these mast cell secretagogues activate G proteins directly via an interaction with the C-terminus of α subunits of G proteins by mimicking the agonist-liganded receptors. © 1990.

引用

页码：355 / 357

页数：3

共 6 条

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[3] MOUSLI M, 1989, J PHARMACOL EXP THER, V250, P329
[4] DIRECT ACTIVATION OF GTP-BINDING REGULATORY PROTEINS (G-PROTEINS) BY SUBSTANCE-P AND COMPOUND 48/80
MOUSLI, M
BRONNER, C
LANDRY, Y
BOCKAERT, J
ROUOT, B
[J]. FEBS LETTERS, 1990, 259 (02): : 260 - 262
[5] MAST-CELL ACTIVATION - A RECEPTOR-INDEPENDENT MODE OF SUBSTANCE-P ACTION
REPKE, H
BIENERT, M
[J]. FEBS LETTERS, 1987, 221 (02) : 236 - 240
[6] RUOUT B, 1989, BIOCHEM J, V260, P307

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