STUDIES OF THE KINETICS OF THE REDUCTION OF CHROMATE BY GLUTATHIONE AND RELATED THIOLS

被引：34

作者：

OBRIEN, P

WANG, GF

WYATT, PB

机构：

[1] Department of Chemistry, Queen Mary and Westfield College, University of London, London, E1 4NS, Mile End Road

来源：

POLYHEDRON | 1992年 / 11卷 / 24期

关键词：

D O I：

10.1016/S0277-5387(00)83664-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reduction of chromate by glutathione, its mono- and diethyl esters, L-CySteine, 2-mercapto-propionic acid and mercapto-succinic acid has been studied. The empirical rate law k(obs) = ab[Thiol]2/(1 + b[Thiol]) is obeyed by all of these thiols, at neutral pH. No evidence could be obtained for a first-order pathway in glutathione under these conditions. These observations are used to comment on the stability of intermediates potentially important in explaining chromate toxicity.

引用

页码：3211 / 3216

页数：6

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