STUDIES OF THE KINETICS OF THE REDUCTION OF CHROMATE BY GLUTATHIONE AND RELATED THIOLS

被引：34

作者：

OBRIEN, P

WANG, GF

WYATT, PB

机构：

[1] Department of Chemistry, Queen Mary and Westfield College, University of London, London, E1 4NS, Mile End Road

来源：

POLYHEDRON | 1992年 / 11卷 / 24期

关键词：

D O I：

10.1016/S0277-5387(00)83664-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reduction of chromate by glutathione, its mono- and diethyl esters, L-CySteine, 2-mercapto-propionic acid and mercapto-succinic acid has been studied. The empirical rate law k(obs) = ab[Thiol]2/(1 + b[Thiol]) is obeyed by all of these thiols, at neutral pH. No evidence could be obtained for a first-order pathway in glutathione under these conditions. These observations are used to comment on the stability of intermediates potentially important in explaining chromate toxicity.

引用

页码：3211 / 3216

页数：6

共 25 条

[21] A POTENTIALLY SIGNIFICANT ONE-ELECTRON PATHWAY IN THE REDUCTION OF CHROMATE BY GLUTATHIONE UNDER PHYSIOLOGICAL CONDITIONS [J].

OBRIEN, P ;

WANG, GF .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (09) :690-692

[22] MITOCHONDRIAL REDUCTION OF THE CARCINOGEN CHROMATE - FORMATION OF CHROMIUM(V) [J].

ROSSI, SC ;

GORMAN, N ;

WETTERHAHN, KE .

CHEMICAL RESEARCH IN TOXICOLOGY, 1988, 1 (02) :101-107

[23] CHROMIUM(V) AND HYDROXYL RADICAL FORMATION DURING THE GLUTATHIONE REDUCTASE-CATALYZED REDUCTION OF CHROMIUM(VI) [J].

SHI, XL ;

DALAL, NS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (01) :627-634

[24]

WONG DWJ, 1984, INORG CHEM, V23, P2528

[25]

1990, MONOGRAPHS EVALUATIO, V49

← 1 2 3 →