ANTIBACTERIAL PHLOROGLUCINOLS AND FLAVONOIDS FROM HYPERICUM BRASILIENSE

被引：158

作者：

ROCHA, L

MARSTON, A

POTTERAT, O

KAPLAN, MAC

EVANS, HS

HOSTETTMANN, K

机构：

[1] UNIV LAUSANNE, INST PHARMACOGNOISE & PHYTOCHIM, BEP, CH-1015 LAUSANNE, SWITZERLAND

[2] UNIV FED RIO DE JANEIRO, NPPN, BR-21941 RIO DE JANEIRO, BRAZIL

[3] UNIV NEUCHATEL, INST CHIM, CH-2000 NEUCHATEL, SWITZERLAND

来源：

PHYTOCHEMISTRY | 1995年 / 40卷 / 05期

关键词：

HYPERICUM BRASILIENSE; GUTTIFERAE; PHLOROGLUCINOLS; HYPERBRASILOL A; ANTIBACTERIAL ACTIVITY; BACILLUS SUBTILIS; FLAVONOIDS;

D O I：

10.1016/0031-9422(95)00507-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three known phloroglucinols (japonicine A, uliginosin A and isouliginosin B) and a new phloroglucinol (hyperbrasilol A) have been isolated from a petrol extract of the leaves and flowers of Hypericum brasiliense. Their Structures were established by spectroscopic methods (UV, DCI-MS, H-1 and C-13 NMR, including SINEPT, HMBC, HSQC, DQFCOSY experiments). The substitution pattern of hyperbrasilol A was confirmed by X-ray crystallography. All four phloroglucinols were antibacterial against Bacillus subtilis in a TLC bioautographic assay. The flavonoids, kaempferol, luteolin, quercetin, quercitrin, isoquercitrin, hyperoside and guaijaverin, were isolated from a methanol extract of the same organs.

引用

页码：1447 / 1452

页数：6

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