NEW DIOL METABOLITES DERIVED BY BIOOXIDATION OF CHLOROSTYRENES WITH PSEUDOMONAS-PUTIDA - DETERMINATION OF ABSOLUTE STEREOCHEMISTRY AND ENANTIOMERIC EXCESS BY CONVERGENT SYNTHESES

被引：43

作者：

HUDLICKY, T

BOROS, EE

BOROS, CH

机构：

[1] Department of Chemistry, Virginia Polytechnic Institute, State University Blacksburg

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(00)80247-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The three isomers of Chlorostyrenes were subjected to whole cell biooxidation by means of a mutant strain of Pseudomonas putida 39D. The metabolites were isolated and their absolute stereochemistry determined by conversion to known standards derived from 1-ethenyl-2,3-dihydroxycyclohexa-4,6-diene whose absolute configuration has been previously established. The extent of ring vs side chain oxidation of the chlorostyrene isomers was evaluated and the enantiomeric excess determined for all compounds.

引用

页码：1365 / 1386

页数：22

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