HIERARCHIES OF DNA-REPAIR IN MAMMALIAN-CELLS - BIOLOGICAL CONSEQUENCES

被引：46

作者：

MULLENDERS, LHF ^{[1
]}

VRIELING, H ^{[1
]}

VENEMA, J ^{[1
]}

VANZEELAND, AA ^{[1
]}

机构：

[1] INTERUNIV RES INST RADIOPATHOL & RADIAT PROTECT,JA COHEN INST,LEIDEN,NETHERLANDS

来源：

MUTATION RESEARCH | 1991年 / 250卷 / 1-2期

关键词：

DNA REPAIR; HIERARCHY; MAMMALIAN CELLS; BIOLOGICAL CONSEQUENCES;

D O I：

10.1016/0027-5107(91)90179-R

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mammalian cells exposed to genotoxic agents exhibit heterogeneous levels of repair of certain types of DNA damage in various genomic regions. For UV-induced cyclobutane pyrimidine dimers we propose that at least three levels of repair exist: (1) slow repair of inactive (X-chromosomal) genes, (2) fast repair of active housekeeping genes, and (3) accelerated repair of the transcribed strand of active genes. These hierarchies of repair may be related to chromosomal banding patterns as obtained by Giemsa staining. The possible consequences of defective DNA repair in one or more of these levels may be manifested in different clinical features associated with UV-sensitive human syndromes. Moreover, molecular analysis of hprt mutations reveals that mutations are primarily generated by DNA damage in the poorly repaired non-transcribed strand of the gene.

引用

页码：223 / 228

页数：6

共 27 条

[21] THE RESIDUAL REPAIR CAPACITY OF XERODERMA PIGMENTOSUM COMPLEMENTATION GROUP-C FIBROBLASTS IS HIGHLY SPECIFIC FOR TRANSCRIPTIONALLY ACTIVE DNA [J].

VENEMA, J ;

VANHOFFEN, A ;

NATARAJAN, AT ;

VANZEELAND, AA ;

MULLENDERS, LHF .

NUCLEIC ACIDS RESEARCH, 1990, 18 (03) :443-448

[22] THE GENETIC-DEFECT IN COCKAYNE SYNDROME IS ASSOCIATED WITH A DEFECT IN REPAIR OF UV-INDUCED DNA DAMAGE IN TRANSCRIPTIONALLY ACTIVE DNA [J].

VENEMA, J ;

MULLENDERS, LHF ;

NATARAJAN, AT ;

VANZEELAND, AA ;

MAYNE, LV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) :4707-4711

[23]

VENEMA J, 1991, IN PRESS MOL CELL BI

[24] MOLECULAR ANALYSIS OF MUTATIONS INDUCED BY N-ETHYL-N-NITROSOUREA AT THE HPRT LOCUS IN MOUSE LYMPHOMA-CELLS [J].

VRIELING, H ;

NIERICKER, MJ ;

SIMONS, JWIM ;

VANZEELAND, AA .

MUTATION RESEARCH, 1988, 198 (01) :99-106

[25]

VRIELING H, 1991, IN PRESS NUCLEIC ACI

[26] MID-PROPHASE HUMAN-CHROMOSOMES - THE ATTAINMENT OF 2000 BANDS [J].

YUNIS, JJ .

HUMAN GENETICS, 1981, 56 (03) :293-298

[27] SUPERCOILED LOOPS AND THE ORGANIZATION OF REPLICATION AND TRANSCRIPTION IN EUKARYOTES [J].

ZEHNBAUER, BA ;

VOGELSTEIN, B .

BIOESSAYS, 1985, 2 (02) :52-54

← 1 2 3 →