DISTENSIBILITY OF SMALL ARTERIES OF THE DOG LUNG

被引:41
作者
ALTINAWI, A
MADDEN, JA
DAWSON, CA
LINEHAN, JH
HARDER, DR
RICKABY, DA
机构
[1] ZABLOCKI VET AFFAIRS MED CTR,RES SERV,5000 W NATL AVE,MILWAUKEE,WI 53295
[2] MARQUETTE UNIV,DEPT BIOMED ENGN,MILWAUKEE,WI 53233
[3] MED COLL WISCONSIN,DEPT NEUROL,MILWAUKEE,WI 53225
关键词
SEROTONIN; PULMONARY ANGIOGRAPHY; ISOLATED LUNGS; ISOLATED VESSELS;
D O I
10.1152/jappl.1991.71.5.1714
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To obtain in situ measurements of the distensibility of small (100- to 1,000-mu-m-diam) pulmonary arterial vessels of the dog lung, X-ray angiograms were obtained from isolated lung lobes with the vascular pressure adjusted to various levels. The in situ diameter-pressure relationships were compared with the diameter-pressure relationships for small arteries that were dissected free from the lungs and cannulated with small glass pipettes for the measurement of diameter and transmural pressure. The diameter-vascular or diameter-transmural pressure curves from both in situ and cannulated vessels were sufficiently linear in the pressure range studied (0-30 Torr) that they could be characterized by linear regression to obtain estimates of D0, the diameter at zero vascular pressure, and beta, the change in diameter (mu-m) per Torr change in pressure. The vessel distensibility coefficient (alpha) was defined as alpha = beta/D0. The mean values of alpha-were approximately 2.0 +/- 0.8%/Torr (SD) for the in situ vessels and 1.7 +/- 0.6%/Torr for the cannulated vessels, with no statistically significant difference between the two methods. The influence of vasoconstriction elicited by serotonin was evaluated in the in situ vessels. Serotonin-induced vasoconstriction caused a decrease in D0 and little change in alpha.
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页码:1717 / 1722
页数:6
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