INDUCTION OF HEAT-SHOCK PROTEIN CLOSELY CORRELATES WITH PROTECTION AGAINST TOXOPLASMA-GONDII INFECTION

被引:37
作者
NAGASAWA, H [1 ]
OKA, M [1 ]
MAEDA, K [1 ]
CHAI, JG [1 ]
HISAEDA, H [1 ]
ITO, Y [1 ]
GOOD, RA [1 ]
HIMENO, K [1 ]
机构
[1] UNIV S FLORIDA, ALL CHILDRENS HOSP, DEPT PEDIAT, ST PETERSBURG, FL 33701 USA
关键词
PROTECTIVE IMMUNE RESPONSE; PARASITE INFECTION; BODY DEFENSE;
D O I
10.1073/pnas.89.7.3155
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides that appear to be produced by many cells to preserve cellular functions under a variety of conditions of stress, including infections. We report that a 65-kDa HSP is present in mouse peritoneal cells that have been infected with a low-virulence (Beverley) strain of Toxoplasma gondii, as determined by electroblot assay using a monoclonal antibody specific for microbial HSP65. This HSP is, however, not expressed when infection occurs with the high-virulence RH strain of T. gondii. Furthermore, HSP was demonstrable in mice that acquired resistance against infection with a lethal dose of bradyzoites of the Beverley strain or even of an inoculum of a highly virulent strain of T. gondii (RH). From these results, it can be suggested that HSPs play an important role in developing effective defenses that include effective immune responses against infection with Toxoplasma parasites in vivo.
引用
收藏
页码:3155 / 3158
页数:4
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