FISHING FOR DRUGS FROM THE SEA - STATUS AND STRATEGIES

被引：57

作者：

DEVRIES, DJ ^{[1
]}

BEART, PM ^{[1
]}

机构：

[1] MONASH UNIV,DEPT PHARMACOL,CLAYTON,VIC 3168,AUSTRALIA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1995年 / 16卷 / 08期

关键词：

D O I：

10.1016/S0165-6147(00)89045-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Marine organisms represent an enormous, essentially unexploited, resource of natural products. Globally, the race to develop marine-derived drugs is well under way with many pharmaceutical companies positioning themselves to reap large profits by the exploitation of the ocean's rich chemical diversity. Targeted strategies, often in combination with high-throughput screening, are being employed in this hunt for novel pharmacotherapeutic agents. David de Vries and Phil Beart examine the potential, problems and technologies of an international pharmaceutical search that has important ethical considerations.

引用

页码：275 / 279

页数：5

共 37 条

[1]

ANDERSEN PH, 1993, Patent No. 9324629

[2]

BACH A, 1993, Patent No. 9323536

[3] IDENTIFYING SMALL-MOLECULE LEAD COMPOUNDS - THE SCREENING APPROACH TO DRUG DISCOVERY [J].

BEVAN, P ;

RYDER, H ;

SHAW, A .

TRENDS IN BIOTECHNOLOGY, 1995, 13 (03) :115-121

[4] NEW LEUKOTRIENE-B4 RECEPTOR ANTAGONIST - LEUCETTAMINE-A AND RELATED IMIDAZOLE ALKALOIDS FROM THE MARINE SPONGE LEUCETTA-MICRORAPHIS [J].

CHAN, GW ;

MONG, S ;

HEMLING, ME ;

FREYER, AJ ;

OFFEN, PH ;

DEBROSSE, CW ;

SARAU, HM ;

WESTLEY, JW .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (01) :116-121

[5] PROTEIN-KINASE-C INHIBITORS - NOVEL SPIROSESQUITERPENE ALDEHYDES FROM A MARINE SPONGE AKA (=SIPHONODICTYON) CORALLIPHAGUM [J].

CHAN, JA ;

FREYER, AJ ;

CARTE, BK ;

HEMLING, ME ;

HOFMANN, GA ;

MATTERN, MR ;

MENTZER, MA ;

WESTLEY, JW .

JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1994, 57 (11) :1543-1548

[6]

CREWS CM, 1994, J BIOL CHEM, V269, P15411

[7] DEMONSTRATION OF SUB-NANOMOLAR AFFINITY OF BRYOSTATIN-1 FOR THE PHORBOL ESTER RECEPTOR IN RAT-BRAIN [J].

DEVRIES, DJ ;

HERALD, CL ;

PETTIT, GR ;

BLUMBERG, PM .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (21) :4069-4073

[8] IDENTIFICATION OF MARINE ORGANISM EXTRACTS ACTIVE AT THE EGF BINDING-SITE OF HUMAN A431 CELLS [J].

DEVRIES, DJ ;

MCCAULEY, RD ;

WALKER, F .

TOXICON, 1994, 32 (05) :553-559

[9] MARINE BIODIVERSITY AS A SOURCE OF CHEMICAL DIVERSITY [J].

DEVRIES, DJ ;

HALL, MR .

DRUG DEVELOPMENT RESEARCH, 1994, 33 (02) :161-173

[10]

FAULKNER DJ, 1994, NAT PROD REP, V11, P333

← 1 2 3 4 →