THE HUMAN IMMUNE-SYSTEM IN HU-PBL-SCID MICE

被引：123

作者：

TARYLEHMANN, M ^{[1
]}

SAXON, A ^{[1
]}

LEHMANN, PV ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DIV CLIN IMMUNOL ALLERGY,LOS ANGELES,CA 90024

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 11期

关键词：

D O I：

10.1016/0167-5699(95)80046-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Severe combined immunodeficiency (SCID) mice can be stably grafted with human peripheral blood lymphocytes, creating hu-PBL-SCID chimeras; essentially, these are mice with a human immune system. Here, Magdalena Tary-Lehmann, Andrew Saxon and Paul Lehmann discuss the immunobiology of these chimeras. The authors propose that hu-PBL-SCID chimerism evolves in two phases. During the first three weeks after grafting, many of the injected cells survive and the human immune system is functional. Subsequently, anti-mouse-reactive clones are selected and the immune system becomes nonfunctional. The implications of this scenario for the utilization of the hu-PBL-SCID model are discussed.

引用

页码：529 / 533

页数：5

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