CHOLECYSTOKININ AND ITS ANTAGONIST LORGLUMIDE RESPECTIVELY ATTENUATE AND FACILITATE MORPHINE-INDUCED INHIBITION OF C-FIBER EVOKED DISCHARGES OF DORSAL HORN NOCICEPTIVE NEURONS

被引：41

作者：

KELLSTEIN, DE

PRICE, DD

MAYER, DJ

机构：

[1] VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT PHYSIOL, RICHMOND, VA 23298 USA

[2] VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT ANESTHESIOL, RICHMOND, VA 23298 USA

来源：

BRAIN RESEARCH | 1991年 / 540卷 / 1-2期

关键词：

CHOLECYSTOKININ; LORGLUMIDE; MORPHINE; NOCICEPTION; C-FIBER; ELECTROPHYSIOLOGY; DORSAL HORN;

D O I：

10.1016/0006-8993(91)90524-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular single unit recordings were made from dorsal horn nociceptive neurons of intact, urethane-anesthetized rats during controlled electrical stimulation of the hind paw. Neither local superfusion of cholecystokinin octapeptide (CCK; 6.4 pmol to 20 nmol) nor the CCK antagonist lorglumide (LGM; 145 fmol to 145 pmol) significantly altered A- or C-fiber evoked firing or spontaneous activity. Pretreatment with CCK, however, significantly attenuated, whereas LGM enhanced, morphine-induced inhibition of C-evoked firing. These findings provide further evidence that CCK functions as a selective antagonist of opioid-induced analgesia.

引用

页码：302 / 306

页数：5

共 33 条

[11] POTENCY OF CR-1409, A NEW PROGLUMIDE ANALOG, ON CHOLECYSTOKININ-MEDIATED BEHAVIORS AND RECEPTOR-BINDING [J].