GLUCOCORTICOID-INDUCED APOPTOSIS OF LYMPHOID-CELLS

被引：104

作者：

SCHWARTZMAN, RA

CIDLOWSKI, JA

机构：

[1] UNIV N CAROLINA, DEPT PHYSIOL, CHAPEL HILL, NC 27599 USA

[2] UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, CHAPEL HILL, NC 27599 USA

[3] UNIV N CAROLINA, CARNEGIE INST WASHINGTON, DEPT EMBRYOL, CHAPEL HILL, NC USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 105卷 / 04期

关键词：

APOPTOSIS; LYMPHOCYTES; GLUCOCORTICOIDS; GLUCOCORTICOID RECEPTOR; ENDONUCLEASES;

D O I：

10.1159/000236781

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The induction of cell death in lymphoid cells by glucocorticoids is one of the earliest and most thoroughly studied models of apoptosis. Although the exact mechanism by which apoptosis occurs in lymphocytes is unknown many biochemical and molecular changes have been shown to occur in these cells in response to glucocorticoids. The role of chromatin degradation and endonucleases in the apoptotic process has been closely studied, as well as the involvement of several once genes in glucocorticoid-induced cell lysis. In addition, the clinical importance of glucocorticoid-induced apoptosis in the treatment of lymphoid neoplasms has recently received increased attention.

引用

页码：347 / 354

页数：8