STEREOCHEMICAL PREFERENCES AND REQUIREMENT FOR THE 3-HYDROXYL GROUP IN NOVEL ANTICONVULSANT 4-FLUOROBENZOYLAMINO BENZOPYRANS

被引：8

作者：

BROWN, TH ^{[1
]}

CAMPBELL, CA ^{[1
]}

CHAN, WN ^{[1
]}

EVANS, JM ^{[1
]}

MARTIN, RT ^{[1
]}

STEAN, TO ^{[1
]}

STEMP, G ^{[1
]}

STEVENS, NC ^{[1
]}

THOMPSON, M ^{[1
]}

UPTON, N ^{[1
]}

VONG, AK ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AW,ESSEX,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 21期

关键词：

D O I：

10.1016/0960-894X(95)00437-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A cis 3S,4S isomer, derived stereospecifically from an anticonvulsant trans 3R,4S-(para-fluorobenzoylamino)-benzopyran using the DAST reagent, has been shown to possess anticonvulsant properties. In contrast the cis 3R,4R enantiomer did not possess anticonvulsant properties but caused blood pressure to fall.

引用

页码：2563 / 2566

页数：4

共 5 条

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