SYSTEMATIC SYNTHESIS AND ANTIVIRAL EVALUATION OF ALPHA-L-ARABINOFURANOSYL AND 2'-DEOXY-ALPHA-L-ERYTHRO-PENTO-FURANOSYL NUCLEOSIDES OF THE 5 NATURALLY-OCCURRING NUCLEIC-ACID BASES

被引：33

作者：

GENUDELLAC, C

GOSSELIN, G

PUECH, F

HENRY, JC

AUBERTIN, AM

OBERT, G

KIRN, A

IMBACH, JL

机构：

[1] UNIV MONTPELLIER SCI & TECH LANGUEDOC 2,CHIM BIOORGAN LAB,CNRS,UNITE MIXTE RECH SYNTHELABO 112,F-34095 MONTPELLIER 5,FRANCE

[2] UNIV STRASBOURG 1,FAC MED,VIROL LAB,INSERM,U74,F-67070 STRASBOURG,FRANCE

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 06期

关键词：

D O I：

10.1080/07328319108047067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The alpha-L-arabinofuranosyl and 2'-deoxy-alpha-L-erythro-pentofuranosyl analogues of the naturally occurring nucleosides have been synthesized and their antiviral properties examined. The alpha-L-arabinofuranosyl nucleosides were prepared by glycosylation of purine and pyrimidine aglycons with a suitably peracyl-alpha-L-arabinose, followed by removal of the protecting groups. Their 2'-deoxy derivatives were obtained by sequential selective 2'-O-deacylation and deoxygenation. All the prepared compounds were tested for their activity against a variety of RNA and DNA viruses, but they did not show significant antiviral activity.

引用

页码：1345 / 1376

页数：32

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