SYSTEMATIC SYNTHESIS AND ANTIVIRAL EVALUATION OF ALPHA-L-ARABINOFURANOSYL AND 2'-DEOXY-ALPHA-L-ERYTHRO-PENTO-FURANOSYL NUCLEOSIDES OF THE 5 NATURALLY-OCCURRING NUCLEIC-ACID BASES

The alpha-L-arabinofuranosyl and 2'-deoxy-alpha-L-erythro-pentofuranosyl analogues of the naturally occurring nucleosides have been synthesized and their antiviral properties examined. The alpha-L-arabinofuranosyl nucleosides were prepared by glycosylation of purine and pyrimidine aglycons with a suitably peracyl-alpha-L-arabinose, followed by removal of the protecting groups. Their 2'-deoxy derivatives were obtained by sequential selective 2'-O-deacylation and deoxygenation. All the prepared compounds were tested for their activity against a variety of RNA and DNA viruses, but they did not show significant antiviral activity.