IGG PARAPROTEINS IN NEUROLOGICAL DISEASES - LACK OF ASSOCIATION WITH NEUROTROPIC VIRAL BACTERIAL-ANTIGENS

被引：1

作者：

MAVRA, M

LUXTON, R

THOMPSON, EJ

机构：

[1] Institute of Neurology, National Hospital, London, WC1 3BG, Queen Square

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1992年 / 86卷 / 06期

关键词：

IGG PARAPROTEIN; ANTIBODIES; NEUROTROPIC AGENT; NEUROLOGICAL DISORDERS; IMMUNOBLOT;

D O I：

10.1111/j.1600-0404.1992.tb05494.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study we tested the hypothesis that IgG paraproteins in neurological diseases might be regarded as an anti-idiotypic response raised by a nervous system antigen associated with certain neurotropic agents. After initial ELISA screen, positive samples from 34 neurological patients who had paraproteins in their CSF and serum on routine IEF investigation, were tested by immunoblot technique for the presence of specific monoclonal immunoglobulin G (IgG) against eight different neurotropic antigens. Only one patient had specific monoclonal IgG against herpes simplex virus. The results of this study did not confirm our hypothesis. Further study of IgM/IgA paraproteins is indicated.

引用

页码：596 / 598

页数：3

共 16 条

[1] ANTI-IDIOTYPIC B-CELL LINES FROM A PATIENT WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE [J].