NEOSTIGMINE STIMULATES GROWTH HORMONE-RELEASING HORMONE-RELEASE INTO HYPOPHYSEAL PORTAL BLOOD OF CONSCIOUS SHEEP

被引：40

作者：

MAGNAN, E ^{[1
]}

CATALDI, M ^{[1
]}

GUILLAUME, V ^{[1
]}

MAZZOCCHI, L ^{[1
]}

DUTOUR, A ^{[1
]}

CONTEDEVOLX, B ^{[1
]}

GIRAUD, P ^{[1
]}

OLIVER, C ^{[1
]}

机构：

[1] FAC MED SECTEUR NORD MARSEILLE,NEUROENDOCRINOL EXPTL LAB,INSERM,U297,BLVD P DRAMARD,F-13916 MARSEILLE 20,FRANCE

来源：

ENDOCRINOLOGY | 1993年 / 132卷 / 03期

关键词：

D O I：

10.1210/en.132.3.1247

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

GH secretion is stimulated by the administration of cholinesterase inhibitors (such as pyridostigmine and neostigmine) in several species, including man. On the basis of indirect experiments, it has been postulated that this action is mediated by a decrease in hypothalamic somatostatin release. We have investigated the effect of neostigmine in sheep, since it is possible to collect hypophysial portal blood for GH-releasing hormone (GHRH) and somatostatin determination in this species under a conscious unstressed state. First, after iv injection of neostigmine (1 mg), a significant increase in plasma GH levels and an unequivocal potentiation of the GH response to GHRH were observed. Then, we observed that iv injection of neostigmine (1 mg) induced an immediate, short-lasting (30 min), and marked increase in GHRH (126.1 +/- 17 vs. 14.5 +/- 2.1 Pg/ml; P < 0.01) levels in hypophysial portal blood of rams chronically implanted with perihypophysial cannulae. No change in somatostatin secretion was recorded during the same period. These data suggest that the stimulating effect of cholinergic drugs on GH secretion is mediated by stimulation of GHRH release. A direct effect of neostigmine at the level of pituitary gland is possible and may explain the potentiation of GHRH-induced GH release.

引用

页码：1247 / 1251

页数：5

共 37 条

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