INTRODUCTION OF PLURAL ASYMMETRIC CENTERS BY A BETA-KETO ESTER REDUCTASE FROM BAKERS-YEAST

被引：11

作者：

KAWAI, Y

HIDA, K

NAKAMURA, K

OHNO, A

机构：

[1] Institute for Chemical Research, Kyoto University, Uji, Kyoto

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 04期

关键词：

D O I：

10.1016/0040-4039(94)02260-I

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A beta-keto ester reductase from baker's yeast catalyzes asymmetric reduction accompanied by simultaneous kinetic resolution of dynamic and static optically active centers. The reduction of 1'-arylethyl 2-methyl-3-oxobutanoates mediated by this enzyme affords the corresponding (1'R)-1'-arylethyl (2R,3S)-3-hydroxy-2-methylbutanoates with excellent stereoselectivity.

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页码：591 / 592

页数：2

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