CALCIUM REGULATION OF GENE-EXPRESSION IN NEURONS - THE MODE OF ENTRY MATTERS

被引：104

作者：

GALLIN, WJ

GREENBERG, ME

机构：

[1] CHILDRENS HOSP, DEPT NEUROL, DIV NEUROSCI, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, CAMBRIDGE, MA 02138 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/0959-4388(95)80050-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ca2+ entry into neurons is one of the major effecters of stimulus-induced physiological change. Ca2+ can enter neurons through a number of different voltage-gated and ligand-gated channels. Depending on the route of entry, Ca2+ stimulates distinct intracellular signaling pathways, which activate different sets of genes, resulting in alternative physiological outcomes for the cell. These recent results suggest that the specific effect of a single biochemical second messenger can vary as a consequence of its route of entry into the cell.

引用

页码：367 / 374

页数：8

共 61 条

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