PROTECTION AGAINST 7,12-DIMETHYLBENZANTHRACENE-INDUCED TUMOR INITIATION BY PROTEIN-A IN MOUSE SKIN

被引：18

作者：

KUMAR, S ^{[1
]}

SHUKLA, Y ^{[1
]}

PRASAD, AK ^{[1
]}

VERMA, AS ^{[1
]}

DWIVEDI, PD ^{[1
]}

MEHROTRA, NK ^{[1
]}

RAY, PK ^{[1
]}

机构：

[1] IND TOXICOL RES CTR,MAHATMA GANDHI MARG,PB 80,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

CANCER LETTERS | 1992年 / 61卷 / 02期

关键词：

PROTEIN-A; 7,12-DIMETHYLBENZANTHRACENE; TUMOR INITIATION; MOUSE SKIN;

D O I：

10.1016/0304-3835(92)90167-T

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Protein A is an immunostimulating glycoprotein obtained from Staphylococcus aureus Cowan I. Its antitumour activity is proven in various tumour models. Its ability to provide protection against tumour initiation by the chemical carcinogen 7,12-dimethylbenzanthracene (DMBA) has been investigated in the present study using a mouse skin model of two-stage carcinogenesis. Protein A was administered intraperitoneally (1-mu-g/animal 20 g body wt.) twice a week for 2 weeks, prior to initiation by DMBA. The promotion was performed by twice weekly applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) (3 or 5-mu-g/animal in 100-mu-l acetone). Protein A provided significant protection to animals from DMBA-induced tumour initiation as was observed by the decrease in cumulative number of tumours, precent of animals developing tumours, number of tumours per animal and rate of tumour growth. Our data indicate that protein A has anticarcinogenic properties.

引用

页码：105 / 110

页数：6

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