INVOLVEMENT OF SEROTONIN IN DEVELOPMENTAL PLASTICITY OF KITTEN VISUAL-CORTEX

被引：140

作者：

GU, Q ^{[1
]}

SINGER, W ^{[1
]}

机构：

[1] MAX PLANCK INST BRAIN RES,DEPT NEUROPHYSIOL,D-60528 FRANKFURT,GERMANY

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1995年 / 7卷 / 06期

关键词：

OCULAR DOMINANCE; MONOCULAR DEPRIVATION; 5,7-DIHYDROXYTRYPTAMINE; KETANSERIN; METHYSERGIDE;

D O I：

10.1111/j.1460-9568.1995.tb01104.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During a critical period of postnatal development, neuronal connections in the kitten visual cortex are susceptible to experience-dependent modifications. These modifications are facilitated by the neuromodulators noradrenaline and acetylcholine. To address the question of whether serotonin (5-hydroxytryptamine; 5-HT), the other major neuromodulator in the cerebral cortex, also plays a role in developmental plasticity, we investigated whether interference with serotoninergic transmission in the kitten visual cortex affects ocular dominance (OD) plasticity. The serotonin neurotoxin 5,7-dihydroxytryptamine or the serotonin receptor blockers ketanserin and methysergide were infused into the visual cortex of kittens undergoing monocular deprivation. We found that both methods of disrupting serotoninergic transmission reduced OD plasticity. However, to be effective, the receptor blockers ketanserin and methysergide had to be applied in combination, suggesting that coactivation of serotonin receptor subtypes of both the 5-HT1 and 5-HT2 families have a permissive function in OD plasticity. Since activation of 5-HT2 receptors stimulates phosphoinositide hydrolysis, our data suggest that second messengers from the phospholipid pathway may play an important role in developmental plasticity of visual cortex.

引用

页码：1146 / 1153

页数：8

共 68 条

[41] Markram H., Segal M., Long‐lasting facilitation of excitatory postsynaptic potentials in the rat hippocampus by acetylcholine, J. Physiol. (Lond.), 427, pp. 381-393, (1990)
[42] Markram H., Segal M., The inositol 1,4,5‐triphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA, J. Physiol., 447, pp. 513-533, (1992)
[43] Martin G.B., Humphrey P.P.A., Classification review: receptors for 5‐hydroxytryptamine: current perspectives on classification and nomenclature, Neuropharmacology, 33, pp. 261-273, (1994)
[44] McCormick D.A., Prince D.A., Two types of muscarinic responses to acetylcholine in mammalian cortical neurons, Proc. Natl Acad. Sci. USA, 82, pp. 6344-6348, (1985)
[45] Meister M., Wong R.O.L., Baylor D.A., Shatz C.J., Synchronous bursts of action potentials in ganglion cells of the developing mammalian retina, Science, 252, pp. 939-943, (1991)
[46] Miller K.D., Chapman B., Stryker M.P., Visual responses in adult visual cortex depend on NMDA receptors, Proc. Natl Acad. Sci. USA, 86, pp. 5183-5187, (1989)
[47] Movshon J.A., Van Sluyters R.C., Visual neural development, Annu. Rev. Psychol., 32, pp. 477-522, (1981)
[48] Mower G.D., Comparison of serotonin 5‐HT receptors and innervation in the visual cortex of normal and dark‐reared cats, J. Comp. Neurol., 312, pp. 223-230, (1991)
[49] Nedergaard S., Engberg I., Flatman J.A., The modulation of excitatory amino acid responses by serotonin in the cat neocortex, Cell. Mol. Neurobiol., 7, pp. 367-379, (1987)
[50] Paradiso M.A., Bear M.F., Daniels J.D., Effects of intracortical infusion of 6‐hydroxydopamine on the response of kitten visual cortex to monocular deprivation, Exp. Brain Res., 51, pp. 413-422, (1983)

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