VIRUS-LIKE PARTICLES IN MDCK CELLS PERSISTENTLY INFECTED WITH BORNA-DISEASE VIRUS

被引：11

作者：

COMPANS, RW ^{[1
]}

MELSEN, LR ^{[1
]}

DELATORRE, JC ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT NEUROPHARMACOL, DIV VIROL, LA JOLLA, CA 92037 USA

来源：

VIRUS RESEARCH | 1994年 / 33卷 / 03期

关键词：

MADIN DARBY CANINE KIDNEY CELL; BORNA DISEASE;

D O I：

10.1016/0168-1702(94)90107-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A line of Madin Darby canine kidney (MDCK) cells persistently infected with Borna disease virus was examined by electron microscopy. Thin sections revealed the presence of intracytoplasmic virus-like particles ranging from 50-100 nm in diameter. Nuclei of the infected cells exhibited accumulation of electron-dense granular structures 15-18 nm in diameter. The intracytoplasmic particles were roughly spherical with a limiting membrane, suggesting the presence of a lipid-containing envelope. The internal structure consisted of strand-like material which in some cases was condensed underneath the envelope. The possible relationship of these particles to Borna disease virions is discussed.

引用

页码：261 / 268

页数：8

共 22 条

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