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FUNCTIONAL DOMAINS OF THE GONADOTROPIN-RELEASING-HORMONE RECEPTOR

被引：39
作者：
SEALFON, SC
MILLAR, RP
机构：
[1] CUNY MT SINAI SCH MED, DEPT NEUROL, NEW YORK, NY 10029 USA
[2] UNIV CAPE TOWN, SCH MED,DEPT CHEM PATHOL,MRC, REGULATORY PEPTIDES RES UNIT, CAPE TOWN 7925, SOUTH AFRICA
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 1995年 / 15卷 / 01期
关键词：
CDNA; GENE STRUCTURE; MUTAGENESIS; RECEPTOR MODEL; BINDING SITE;
D O I：
10.1007/BF02069557
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
1. The cloning of the mammalian gonadotropin-releasing hormone receptor sets the stage for rapid progress in understanding the structure of the receptor, its interaction with ligand, and its mechanisms of activation. 2. The receptor is a 327 to 328-amino acid seven-transmembrane domain G protein-coupled receptor. 3. Recent site-direct mutagenesis studies have provided considerable insight into glycosylation of the receptor, the arrangement of the helices, and the ligand binding domains.
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收藏
页码：25 / 42
页数：18
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