FUNCTIONAL DOMAINS OF THE GONADOTROPIN-RELEASING-HORMONE RECEPTOR

被引：39

作者：

SEALFON, SC

MILLAR, RP

机构：

[1] CUNY MT SINAI SCH MED, DEPT NEUROL, NEW YORK, NY 10029 USA

[2] UNIV CAPE TOWN, SCH MED,DEPT CHEM PATHOL,MRC, REGULATORY PEPTIDES RES UNIT, CAPE TOWN 7925, SOUTH AFRICA

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1995年 / 15卷 / 01期

关键词：

CDNA; GENE STRUCTURE; MUTAGENESIS; RECEPTOR MODEL; BINDING SITE;

D O I：

10.1007/BF02069557

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. The cloning of the mammalian gonadotropin-releasing hormone receptor sets the stage for rapid progress in understanding the structure of the receptor, its interaction with ligand, and its mechanisms of activation. 2. The receptor is a 327 to 328-amino acid seven-transmembrane domain G protein-coupled receptor. 3. Recent site-direct mutagenesis studies have provided considerable insight into glycosylation of the receptor, the arrangement of the helices, and the ligand binding domains.

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收藏

页码：25 / 42

页数：18

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