COMPARATIVE ANTIFUNGAL EFFECT AND MODE OF ACTION OF TETRACONAZOLE ON USTILAGO-MAYDIS

被引：7

作者：

CARZANIGA, R ^{[1
]}

CARELLI, A ^{[1
]}

FARINA, G ^{[1
]}

ARNOLDI, A ^{[1
]}

GOZZO, F ^{[1
]}

机构：

[1] UNIV MILAN,DIPARTIMENTO SCI MOLEC AGROALIMENTARI,SEZ CHIM,I-20133 MILAN,ITALY

来源：

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | 1991年 / 40卷 / 03期

关键词：

ERGOSTEROL BIOSYNTHESIS; FUNGICIDE 1-<2-(2,4-DICHLOROPHENYL)-4-ETHYL-1,3-DIOXOLAN-2-YLMETHYL>-1H-1,2,4-TR; INHIBITION; DERIVATIVES; METABOLISM; STEROLS; YEAST;

D O I：

10.1016/0048-3575(91)90099-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tetraconazole, a new, recently introduced antifungal triazole, has been assayed in parallel with a number of standard analogues on various sensitive strains of Ustilago maydis. The values of EC50 and EC90 tetraconazole concentrations, determined on strain ATCC 14826 in agar, were 0.5 × 10-6 and 3.5 × 10-5 m, respectively, in reasonable agreement with those needed to inhibit by 50% and 90%, respectively, the ergosterol biosynthesis in broth cultures. Squalene and 12 sterols have been extracted from the latter, characterized and quantified. Accumulation of 14α-methylsterols and reduction of ergosterol and other late precursors are consistent with the inhibition of 14α-demethylase caused by the title compound. © 1991.

引用

页码：274 / 283

页数：10

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