BETA-1 INTEGRINS IN 3RD-TRIMESTER HUMAN PLACENTAE - NO DIFFERENTIAL EXPRESSION IN PATHOLOGICAL PREGNANCY

被引:28
作者
DIVERS, MJ
BULMER, JN
MILLER, D
LILFORD, RJ
机构
[1] ST JAMES UNIV HOSP,DEPT OBSTET,LEEDS LS9 7TF,W YORKSHIRE,ENGLAND
[2] UNIV NEWCASTLE UPON TYNE,SCH PATHOL SCI,DIV PATHOL,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND
[3] UNIV LEEDS,DEPT CLIN MED,ACAD UNIT PATHOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
[4] INST EPIDEMIOL & HLTH SERV RES,LEEDS,W YORKSHIRE,ENGLAND
关键词
D O I
10.1016/0143-4004(95)90112-4
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Integrins are a group of cell surface receptors that play important roles in cell-cell and cell-extracellular matrix interactions. The expression of trophoblast cell surface integrin subunits changes during placental development in normal pregnancy but the functional significance is unknown. The aim of this study was to investigate the expression of beta 1 integrins and their extracellular matrix ligands in human placenta and membranes in normal and pathological pregnancy using an avidin-biotin-peroxidase technique. Expression of the beta 1 integrins was similar in all study groups. Whilst there mas some heterogeneity of expression of specific integrin a chains this was nos characteristic of defined subject groups, variations occurring within all groups. Two distinct trophoblast subpopulations were demonstrated in the chorion laeve according to differential expression of beta 1 integrins. Trophoblast immediately adjacent to maternal decidua, which expressed alpha 1 rather than alpha 2, also comprised the majority of trophoblast in the basal plate; possession of the alpha 1, alpha 3, alpha 5, alpha 6 rather than alpha 2, alpha 3, alpha 5, alpha 6 phenotype may be important in the invasive potential of trophoblast populations. The results obtained in the present study indicate that the integrin phenotypes of third trimester uteroplacental tissues are similar in normal and pathological pregnancy, including pre-eclampsia, before and after labour.
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页码:245 / 260
页数:16
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