NITRIC-OXIDE AND PROSTAGLANDINS INTERACT TO MEDIATE ARTERIOLAR DILATION DURING CORTICAL SPREADING DEPRESSION

被引:27
作者
MENG, W
COLONNA, DM
TOBIN, JR
BUSIJA, DW
机构
[1] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT PHYSIOL & PHARMACOL, WINSTON SALEM, NC 27157 USA
[2] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT ANESTHESIOL, WINSTON SALEM, NC 27157 USA
[3] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, NEUROSCI PROGRAM, WINSTON SALEM, NC 27157 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1995年 / 269卷 / 01期
关键词
N-G-NITRO-L-ARGININE; CEREBRAL CIRCULATION; RABBITS; INDOMETHACIN;
D O I
10.1152/ajpheart.1995.269.1.H176
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We examined whether blockade of prostaglandin synthesis by indomethacin could attenuate the effect of nitric oxide synthase (NOS) inhibition on cerebral arteriolar dilation during cortical spreading depression (CSD). CSD was induced by microinjection of 5% (670 mM) KCl onto the cerebral cortex of anesthetized adult rabbits. A closed cranial window and intravital microscopy were used to measure pial arteriolar diameter, and NOS activity was determined by the conversion assay of [C-14]arginine to [C-14]citrulline. CSD dilated pial arterioles by 47 +/- 3% (baseline = 80-88 mu m) (n = 21, P < 0.05), and inhibition of NOS by NG-nitro-L-arginine (L-NNA) (15 mg/kg iv) reduced dilation during CSD by over one-half(n = 8, P < 0.05) without altering the onset latency to CSD. After indomethacin administration (15 mg/kg iv), CSD dilated arterioles from 73 +/- 2 to 152 +/- 6 mu m (n = 4, P < 0.05). However, after administration of both indomethacin and L-NNA (n = 5), CSD-induced arteriolar dilation was not different from the situation where indomethacin alone was given. Thus indomethacin completely abolished the inhibitory effect of L-NNA on CSD-induced dilation. Administration of L-NNA inhibited NOS activity in brain cortex almost completely (n = 8, P < 0.05), whereas indomethacin itself had no effect (n = 8). In addition, L-NNA inhibited topical acetylcholine (10(-5) M)-induced arteriolar dilation (n = 3, P < 0.05), and this effect was not altered by indomethacin (n = 4). In summary, L-NNA reduced arteriolar dilation during CSD. However, after administration of indomethacin, L-NNA does not reduce CSD-induced arteriolar dilation.
引用
收藏
页码:H176 / H181
页数:6
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