KUANONIAMINE-A, KUANONIAMINE-B, KUANONIAMINE-C, AND KUANONIAMINE-D - PENTACYCLIC ALKALOIDS FROM A TUNICATE AND ITS PROSOBRANCH MOLLUSK PREDATOR CHELYNOTUS-SEMPERI

被引：140

作者：

CARROLL, AR ^{[1
]}

SCHEUER, PJ ^{[1
]}

机构：

[1] UNIV HAWAII,DEPT CHEM,HONOLULU,HI 96822

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 14期

关键词：

D O I：

10.1021/jo00301a040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

From a Micronesian tunicate and its predator, a prosobranch mollusk Chelynotus semperi, we have isolated five alkaloids, the known shermilamine B (1) and four new pentacyclic compounds, kuanoniamines A-D (2–5). The structures were established by extensive NMR analysis and correlations. Cytotoxicity (IC50) against KB cells ranged from >10 ug/mL for 3 to 5 ug/mL for 1 and 5 to 1 ug/mL for 2. © 1990, American Chemical Society. All rights reserved.

引用

页码：4426 / 4431

页数：6

共 23 条

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