ACIDIC FIBROBLAST GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN BRAIN OF ALZHEIMER PATIENTS

被引：31

作者：

TOOYAMA, I

AKIYAMA, H

MCGEER, PL

HARA, Y

YASUHARA, O

KIMURA, H

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,KINSMEN LAB NEUROL RES,WESBROOK MALL,VANCOUVER V6T 1W5,BC,CANADA

[2] SHIGA UNIV MED SCI,INST MOLEC NEUROBIOL,DEPT NEUROSURG,OTSU,SHIGA 52021,JAPAN

[3] KYOTO UNIV,DEPT NEUROL,KYOTO 606,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 121卷 / 1-2期

关键词：

ACIDIC FIBROBLAST GROWTH FACTOR; IMMUNOSTAINING; ANTIBODY; HUMAN BRAIN; ALZHEIMER DISEASE; GLIA;

D O I：

10.1016/0304-3940(91)90673-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Localization of acidic fibroblast growth factor (aFGF)-like immunoreactivity was examined in postmortem human brain tissue of Alzheimer and age-matched control cases using a rabbit polyclonal antibody specific for aFGF. In control cases, a small number of glial cells were stained very weakly in white but not in gray matter. In Alzheimer cases, some astrocytes were strongly stained for aFGF in both gray and white matter. These intensely staining cells were frequently observed surrounding senile plaques, but represented a small proportion of the total astrocytic population. The present study suggest that aFGF may be upregulated in areas of Alzheimer pathology.

引用

页码：155 / 158

页数：4