REDUCED MG2+ BLOCK OF N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED SYNAPTIC POTENTIALS IN DEVELOPING VISUAL-CORTEX

被引:81
作者
KATO, N
YOSHIMURA, H
机构
[1] Dept. of Integrative Brain Science, Faculty of Medicine, Kyoto University
关键词
GLUTAMATE; SYNAPTIC TRANSMISSION; NEOCORTEX; NEURAL PLASTICITY; LIGAND-GATED ION CHANNEL;
D O I
10.1073/pnas.90.15.7114
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Molecular cloning has demonstrated a diversity of artificially expressed N-methyl-D-aspartate (NMDA) receptors, implying a similar diversity of naturally occurring NMDA receptors in situ. Particularly significant was the success in expression of NMDA receptor classes exhibiting various sensitivities to Mg2+ block, a voltage-dependent channel blockade by Mg2+ that is essential to NMDA receptor functioning. Release from Mg2+ block often allows or facilitates the occurrence of long-term potentiation, a form of synaptic plasticity. Here we show that in the immature visual cortex, which is more susceptible to long-term potentiation than adult visual cortex, synaptically activated NMDA receptors, unlike those in the adult, have varying but clearly reduced sensitivities to Mg2+ block. We propose that the initially expressed, later-eliminated NMDA receptors exhibiting a reduced Mg2+ block may underlie the greater susceptibility to plasticity in the immature neocortex.
引用
收藏
页码:7114 / 7118
页数:5
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