2 SUBCLONES IN A CASE OF UVEAL MELANOMA - RELEVANCE OF MONOSOMY-3 AND MULTIPLICATION OF CHROMOSOME-8Q

被引：40

作者：

PRESCHER, G

BORNFELD, N

BECHER, R

机构：

[1] UNIV ESSEN GESAMTHSCH KLINIKUM,WESTDEUTSCH TUMORZENTRUM,INNERE KLIN & POLIKLIN TUMORFORSCH,D-45122 ESSEN,GERMANY

[2] UNIV ESSEN GESAMTHSCH,AUGENKLIN,ESSEN,GERMANY

来源：

CANCER GENETICS AND CYTOGENETICS | 1994年 / 77卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)90230-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Monosomy 3 and multiplication of 8q are nonrandom findings in uveal melanoma. We present a case in which two subclones could be detected. Both had monosomy 3 in common. Furthermore, a multiplication of chromosome 8 material was also seen in both subclones. However it was based on different kinds of aberrations and was accompanied by further anomalies, such as loss of a Y-chromosome, an additional chromosome 7, and an additional marker chromosome, in only one clone. This finding allows some insight into the relevance of the most frequently found anomalies of chromosome 3 and 8 in uveal melanoma. As monosomy 3 occurred before any subclone differentiation, it must be an early, if not primary, event in the genesis of this tumor. Multiplication of chromosome 8, specifically of 8q, however may contribute to the clonal evolution of this tumor.

引用

页码：144 / 146

页数：3

共 22 条

[1] THE MYC ONCOGENE - ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION [J].

COLE, MD .

ANNUAL REVIEW OF GENETICS, 1986, 20 :361-384

[2] HOW DO HUMAN ISOCHROMOSOMES ARISE [J].

DELACHAPELLE, A .

CANCER GENETICS AND CYTOGENETICS, 1982, 5 (02) :173-179

[3]

EINHORN LH, 1974, CANCER, V34, P1001, DOI 10.1002/1097-0142(197410)34:4<1001::AID-CNCR2820340406>3.0.CO

[4]

2-Z

[5] TRISOMY-6P IN AN OCULAR MELANOMA [J].

GRIFFIN, CA ;

LONG, PP ;

SCHACHAT, AP .

CANCER GENETICS AND CYTOGENETICS, 1988, 32 (01) :129-132

[6]

HORSMAN DE, 1993, CANCER, V71, P811, DOI 10.1002/1097-0142(19930201)71:3<811::AID-CNCR2820710325>3.0.CO

[7]

2-F

[8] MONOSOMY-3 AND ISOCHROMOSOME-8Q IN A UVEAL MELANOMA [J].

HORSMAN, DE ;

SROKA, H ;

ROOTMAN, J ;

WHITE, VA .

CANCER GENETICS AND CYTOGENETICS, 1990, 45 (02) :249-253

[9] MECHANISM OF I(6P) FORMATION IN RETINOBLASTOMA TUMOR-CELLS [J].

HORSTHEMKE, B ;

GREGER, V ;

BECHER, R ;

PASSARGE, E .

CANCER GENETICS AND CYTOGENETICS, 1989, 37 (01) :95-102

[10] LOSS OF CHROMOSOME-3 ALLELES AND MULTIPLICATION OF CHROMOSOME-8 ALLELES IN UVEAL MELANOMA [J].

HORSTHEMKE, B ;

PRESCHER, G ;

BORNFELD, N ;

BECHER, R .

GENES CHROMOSOMES & CANCER, 1992, 4 (03) :217-221

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