LOSS OF CHROMOSOME-3 ALLELES AND MULTIPLICATION OF CHROMOSOME-8 ALLELES IN UVEAL MELANOMA

被引：54

作者：

HORSTHEMKE, B

PRESCHER, G

BORNFELD, N

BECHER, R

机构：

[1] UNIV ESSEN GESAMTHSCH KLINIKUM,INNERE KLIN & POLIKLIN TUMORFORSCH,W-4300 ESSEN 1,GERMANY

[2] UNIV ESSEN GESAMTHSCH KLINIKUM,ZENTRUM AUGENHEILKUNDE,W-4300 ESSEN 1,GERMANY

来源：

GENES CHROMOSOMES & CANCER | 1992年 / 4卷 / 03期

关键词：

D O I：

10.1002/gcc.2870040305

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Uveal melanoma is the most frequent primary intraocular tumor. The etiology is unknown. Using neutral DNA polymorphisms on chromosomes 2, 3, and 8, we have detected loss of chromosome 3 alleles in 8 of 13 tumors and multiplication of chromosome 8 alleles in 6 of 11 tumors. No anomalies at a locus on chromosome 2 were found in 10 of 10 tumors. These results confirm and extend previous cytogenetic findings and suggest that a tumor suppressor gene on chromosome 3 and an oncogene on chromosome 8 may be involved in the formation or progression of this tumor.

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页码：217 / 221

页数：5

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