SYNTHESIS OF OPTICALLY-ACTIVE ETHANOLAMINES

被引：83

作者：

BRUSSEE, J ^{[1
]}

DOFFERHOFF, F ^{[1
]}

KRUSE, CG ^{[1
]}

VANDERGEN, A ^{[1
]}

机构：

[1] DUPHAR BV,1380 AA WEESP,NETHERLANDS

来源：

TETRAHEDRON | 1990年 / 46卷 / 05期

关键词：

D O I：

10.1016/S0040-4020(01)81972-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(1R,2S)-2-amino-1-arylethanols of high optical purity have been obtained from optically active tert-butyldimethylsilyl protected cyanohydrins by a Grignard reaction, directly followed by reduction of the intermediate imine. Chiral induction gave a large preponderance of the erythro isomers. © 1990.

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页码：1653 / 1658

页数：6

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