SYNTHESIS OF OPTICALLY-ACTIVE ETHANOLAMINES

被引：83

作者：

BRUSSEE, J ^{[1
]}

DOFFERHOFF, F ^{[1
]}

KRUSE, CG ^{[1
]}

VANDERGEN, A ^{[1
]}

机构：

[1] DUPHAR BV,1380 AA WEESP,NETHERLANDS

来源：

TETRAHEDRON | 1990年 / 46卷 / 05期

关键词：

D O I：

10.1016/S0040-4020(01)81972-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(1R,2S)-2-amino-1-arylethanols of high optical purity have been obtained from optically active tert-butyldimethylsilyl protected cyanohydrins by a Grignard reaction, directly followed by reduction of the intermediate imine. Chiral induction gave a large preponderance of the erythro isomers. © 1990.

引用

页码：1653 / 1658

页数：6

共 15 条

[11]

Nagai WN, 1929, LIEBIGS ANN CHEM, V470, P157

[12] STUDIES ON MORPHINE-LIKE COMPOUNDS .5. ABSOLUTE CONFIGURATION AND CONFORMATIONS OF OPTICALLY ACTIVE 1,2-DIPHENYLETHYLAMINE DERIVATIVES [J].