VOLUME, PH, AND ION-CONTENT REGULATION IN HUMAN RED-CELLS - ANALYSIS OF TRANSIENT-BEHAVIOR WITH AN INTEGRATED MODEL

被引：159

作者：

LEW, VL ^{[1
]}

BOOKCHIN, RM ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA

来源：

JOURNAL OF MEMBRANE BIOLOGY | 1986年 / 92卷 / 01期

关键词：

D O I：

10.1007/BF01869016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A basic mathematical model of human red cells is presented which integrates the charge and nonideal osmotic behavior of hemoglobin and of other impermeant cell solutes with the ion transport properties of the red cell membrane. The computing strategy was designed to predict the behavior of all measurable variables in time in ways that optimize comparison with experimentally determined behavior. The need and applications of such a model are illustrated in three separate examples covering different areas of experimentation in the physiology and pathophysiology of red cells.

引用

页码：57 / 74

页数：18

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