AN EVALUATION OF BONE-DENSITY AND TURNOVER IN PREMENOPAUSAL WOMEN WITH TYPE-1 DIABETES-MELLITUS

被引：59

作者：

GALLACHER, SJ

FENNER, JAK

FISHER, BM

QUIN, JD

FRASER, WD

LOGUE, FC

COWAN, RA

BOYLE, IT

MACCUISH, AC

机构：

[1] Diabetic Unit, Royal Liverpool Hospital, Liverpool

[2] University Department of Medicine, Royal Liverpool Hospital, Liverpool

[3] Institute of Biochemistry, Glasgow Royal Infirmary, Royal Liverpool Hospital, Liverpool

[4] University Department of Clinical Chemistry, Royal Liverpool Hospital, Liverpool

来源：

DIABETIC MEDICINE | 1993年 / 10卷 / 02期

关键词：

OSTEOPOROSIS; DIABETES-MELLITUS; BONE DENSITOMETRY; BONE TURNOVER;

D O I：

10.1111/j.1464-5491.1993.tb00029.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Measurement of bone density and turnover was assessed in 20 premenopausal females with Type 1 diabetes mellitus and 27 age-sex-matched controls. Measurement was made of spinal (L2-4) and neck of femur bone density by dual-energy X-ray absorptiometry. L2-4 density was significantly higher in the diabetic patients compared with controls (1.224 +/- 0.021 g cm-2 vs 1.161 +/- 0.020 g cm-2: p = 0.016). No significant difference was noted between the groups in neck of femur density. Measurement of bone formation was assessed by serum alkaline phosphatase and bone resorption by fasting urinary hydroxyproline/creatinine ratio. Alkaline phosphatase was significantly higher in the diabetic patients (185 +/- 16 Ul-1 vs 135 +/- 10 Ul-1: p < 0.01) as was hydroxyproline/creatinine ratio (0.028 +/- 0.003 vs 0.017 +/- 0.002: p = 0.002). No significant correlation was found between L2-4 density and glycated haemoglobin, duration of diabetes or daily dose of insulin taken. These data suggest that osteopenia is not associated with Type 1 diabetes mellitus; however these patients do have evidence of increased bone turnover and may therefore be at risk of osteoporosis in later life, particularly after the menopause.

引用

页码：129 / 133

页数：5

共 28 条

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