LIGANDS FOR EPH-RELATED RECEPTOR TYROSINE KINASES THAT REQUIRE MEMBRANE ATTACHMENT OR CLUSTERING FOR ACTIVITY

被引：647

作者：

DAVIS, S ^{[1
]}

GALE, NW ^{[1
]}

ALDRICH, TH ^{[1
]}

MAISONPIERRE, PC ^{[1
]}

LHOTAK, V ^{[1
]}

PAWSON, T ^{[1
]}

GOLDFARB, M ^{[1
]}

YANCOPOULOS, GD ^{[1
]}

机构：

[1] MT SINAI HOSP, SAMUEL LUNENFELD RES INST, DIV MOLEC & DEV BIOL, TORONTO M5G 1X5, ON, CANADA

来源：

SCIENCE | 1994年 / 266卷 / 5186期

关键词：

D O I：

10.1126/science.7973638

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

The EPH-related transmembrane tyrosine kinases constitute the largest known family of receptor-like tyrosine kinases, with many members displaying specific patterns of expression in the developing and adult nervous system. A family of cell surface-bound ligands exhibiting distinct, but overlapping, specificities for these EPH-related kinases was identified. These ligands were unable to act as conventional soluble factors. However, they did function when presented in membrane-bound form, suggesting that they require direct cell-to-cell contact to activate their receptors. Membrane attachment may serve to facilitate ligand dimerization or aggregation, because antibody-mediated clustering activated previously inactive soluble forms of these ligands.

引用

页码：816 / 819

页数：4