MEASUREMENT OF BLOOD-BRAIN-BARRIER PERMEABILITY USING DYNAMIC GD-DTPA SCANNING - A COMPARISON OF METHODS

被引：59

作者：

LARSSON, HBW ^{[1
]}

TOFTS, PS ^{[1
]}

机构：

[1] INST NEUROL,LONDON WC1N 3BG,ENGLAND

来源：

MAGNETIC RESONANCE IN MEDICINE | 1992年 / 24卷 / 01期

关键词：

D O I：

10.1002/mrm.1910240119

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Two recently published methods of blood‐brain barrier permeability measurement using Gd‐DTPA scanning are compared by authors representing each group. The physiological models are reconciled. Results from both groups agree. These show that the transfer constant (the permeability surface area product per unit volume of tissue) of the defective blood‐brain barrier in multiple sclerosis is in the range 1‐12·10−4s−1 © 1992 Academic Press, Inc. Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company

引用

页码：174 / 176

页数：3

共 5 条

[1] QUANTITATION OF BLOOD-BRAIN-BARRIER DEFECT BY MAGNETIC-RESONANCE-IMAGING AND GADOLINIUM-DTPA IN PATIENTS WITH MULTIPLE-SCLEROSIS AND BRAIN-TUMORS [J].