LAPAROSCOPIC STUDY OF PELIOSIS HEPATIS AND NODULAR TRANSFORMATION OF THE LIVER BEFORE AND AFTER RENAL-TRANSPLANTATION - NATURAL-HISTORY AND ETIOLOGY IN FOLLOW-UP CASES

Although peliosis hepatis and nodular transformation of the liver can occur after renal transplantation, their prevalence has not been well defined. To investigate the incidence of these complications, 137 laparoscopies were studied, 52 in 50 cases before and 85 in 66 cases after renal transplantation. To elucidate the aetiology and natural history of these diseases, cases were followed up by repeated laparoscopies. Peliosis was observed after transplantation (before: n=1, after: n=15 [22%], p<0.005). Nodular transformation was seen only after transplantation (n=5 [7%]), and was accompanied by peliosis (n=4, p<0.01). On observation before and after transplantation in the same cases, these diseases appeared after transplantation (peliosis: n=9, p<0.005; nodular transformation: n=2). In follow-up cases, these diseases were confirmed after the discontinuation of or the controlled administration of immunosuppressants. The aetiology of the micronodular transformation which appeared following peliosis in a case treated without cyclosporin was shown to be azathioprine. However, the macronodular transformation observed in two cases treated with both azathioprine and cyclosporin seemed to be due to cyclosporin. This suggests that cases of peliosis hepatis and nodular transformation which appear after renal transplantation are associated with immunosuppressants, and that cyclosporin treatment may also affect the morphogenesis of nodular transformation. (C) Journal of Hepatology.