AROMATIC ISOSTERES AS CONFORMATIONAL PROBES FOR AN ISOPRENYL SUBUNIT - APPLICATION TO INHIBITORS OF SQUALENE SYNTHASE

被引：26

作者：

BILLER, SA

ABT, JW

PUDZIANOWSKI, AT

RICH, LC

SLUSARCHYK, DA

CIOSEK, CP

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81236-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of aromatic isosteres of the farnesyl chain of potent squalene synthase inhibitor 1 were prepared and evaluated. The results are consistent with the local conformation indicated in structure 2.

引用

页码：595 / 600

页数：6

共 24 条

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