THE VITESSE ALGORITHM FOR RAPID EXACT MULTILOCUS LINKAGE ANALYSIS VIA GENOTYPE SET-RECODING AND FUZZY INHERITANCE

被引：423

作者：

OCONNELL, JR

WEEKS, DE

机构：

[1] UNIV PITTSBURGH,DEPT HUMAN GENET,PITTSBURGH,PA 15261

[2] UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,OXFORD OX3 7BN,ENGLAND

来源：

NATURE GENETICS | 1995年 / 11卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ng1295-402

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

As genetic marker maps have improved, multipoint linkage analysis has become a crucial part of all disease mapping studies. Paradoxically, multipoint rod scores become increasingly difficult to compute, particularly as the numbers of markers, marker alleles and untyped people increase. We have solved this problem by using a novel set-recoding scheme to recode each person's genotype and 'fuzzy inheritance' to infer transmission probabilities. Our approach is implemented in a memory-efficient computer program, VITESSE, for extremely rapid computation of exact multipoint likelihoods. VITESSE enables fast and precise multipoint mapping of disease loci with highly polymorphic markers.

引用

页码：402 / 408

页数：7

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