MOLONEY LEUKEMIA-VIRUS IMMORTALIZES LYMPHOCYTES-B INVITRO

被引：5

作者：

RUNNELS, J

SERUNIAN, L

THURSBY, M

ROSENBERG, N

机构：

[1] TUFTS UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02111

[2] TUFTS UNIV,SCH MED,DEPT MOLEC BIOL & MICROBIOL,BOSTON,MA 02111

[3] HARVARD UNIV,DEPT CELLULAR & DEV BIOL,CAMBRIDGE,MA 02138

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 10期

关键词：

D O I：

10.1128/JVI.65.10.5549-5552.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An in vitro culture system in which Moloney murine leukemia virus induces immortalization of mature B lymphocytes has been developed. The cell lines derived in this way are nontumorigenic, and virus production is not required to sustain them. This system provides a new in vitro model with which to study the stepwise process of transformation by retroviruses lacking oncogenes.

引用

页码：5549 / 5552

页数：4

共 22 条

[11] MECHANISM OF LEUKEMOGENESIS INDUCED BY MINK CELL FOCUS-FORMING MURINE LEUKEMIA VIRUSES [J].