EFFECTS OF VANILLIN AND ORTHO-VANILLIN ON INDUCTION OF DNA-REPAIR NETWORKS - MODULATION OF MUTAGENESIS IN ESCHERICHIA-COLI

被引：29

作者：

TAKAHASHI, K ^{[1
]}

SEKIGUCHI, M ^{[1
]}

KAWAZOE, Y ^{[1
]}

机构：

[1] KYUSHU UNIV 60, FAC MED, DEPT BIOCHEM, FUKUOKA 812, JAPAN

来源：

MUTATION RESEARCH | 1990年 / 230卷 / 02期

关键词：

Adaptive response; Antimutagenesis; Comutagenesis; DNA repair; E; coli; o-Vanillin; SOS response; Vanillin;

D O I：

10.1016/0027-5107(90)90051-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Vanillin and its isomer o-vanillin have an effect on the adaptive and SOS responses, as well as mutagenesis, induced in Escherichia coli by N-methyl-N-nitrosourea (MNU) and UV irradiation, potentiating in some cases and suppressing in others. o-Vanillin markedly inhibited the MNU-induced adaptive response, while both vanillins potentiated the UV-induced SOS response. These phenomena appear to be responsible for the comutagenic or antimutagenic role of these chemicals in MNU and UV mutagenesis. © 1990.

引用

页码：127 / 134

页数：8

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