ASSIGNMENT OF THE GENE CODING FOR THE ALPHA-2-MACROGLOBULIN RECEPTOR TO MOUSE CHROMOSOME-15 AND TO HUMAN CHROMOSOME-12Q13-Q14 BY ISOTOPIC AND NONISOTOPIC INSITU HYBRIDIZATION

被引：19

作者：

HILLIKER, C

VANLEUVEN, F

VANDENBERGHE, H

机构：

[1] Center for Human Genetics, University of Leuven, B-3000, Campus Gasthuisberg O and N

来源：

GENOMICS | 1992年 / 13卷 / 02期

关键词：

D O I：

10.1016/0888-7543(92)90276-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The assignment of the gene encoding the α2-macroglobulin receptor (A2MR), which was first described as the low-density lipoprotein receptor-related protein, was confirmed by nonisotopic and isotopic in situ hybridizations on normal human metaphases to the region 12q13-q14. The same human cDNA, which has 95% sequence identity with the mouse A2mr, was hybridized to metaphases containing the Robertsonian translocation Rb(6;15) 1Ald. The mouse A2mr gene was assigned to chromosome 15 in the region B2-D1. this locus and other loci on mouse chromosome 15 have been shown to be homologous with loci on human chromosome 12q. © 1992.

引用

页码：472 / 474

页数：3

共 18 条

[1]

BALDINI A, 1990, AM J HUM GENET, V46, P784

[2] THE LDL RECEPTOR RELATED PROTEIN, LRP, IS AN APOLIPOPROTEIN-E-BINDING PROTEIN [J].