A CASE-CONTROL INTERVIEW STUDY OF BREAST-CANCER AMONG JAPANESE A-BOMB SURVIVORS .2. INTERACTIONS WITH RADIATION-DOSE

被引：65

作者：

LAND, CE

HAYAKAWA, N

MACHADO, SG

YAMADA, Y

PIKE, MC

AKIBA, S

TOKUNAGA, M

机构：

[1] Radiation Epidemiology Branch, National Cancer Institute, Bethesda, 20852, MD, 6130 Rockville Pike

[2] the Radiation Effects Research Foundation, Hiroshima and Nagasaki

[3] the Research Institute for Nuclear Medicine and Biology, Hiroshima University, Hiroshima

[4] the Food and Drug Administration, Rockville, MD

[5] Department of Community Medicine, University of Southern California, Los Angeles, CA

[6] Kagoshima City Hospital, Kagoshima

来源：

CANCER CAUSES & CONTROL | 1994年 / 5卷 / 02期

关键词：

A-BOMB SURVIVORS; BREAST CANCER; IONIZING RADIATION; JAPAN; REPRODUCTIVE HISTORY;

D O I：

10.1007/BF01830263

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three breast cancer risk factors were evaluated in terms of their interactions with radiation dose in a case-control interview study of Japanese A-bomb survivors. Cases and controls were matched on age at the time of the bombings and radiation dose, and dose-related risk was estimated from cohort rather than case-control data. Each factor-age at first full-term pregnancy, number of deliveries, and cumulative lactation period summed over births-conformed reasonably well to a multiplicative interaction model with radiation dose (the additive interactive model, in which the absolute excess risk associated with a factor is assumed to be independent of radiation dose, was rejected). An important implication of the finding is that early age at first full-term pregnancy, multiple births, and lengthy cumulative lactation are all protective against radiation-related, as well as baseline, breast cancer. Analyses by age at exposure to radiation suggest that, among women exposed to radiation in childhood or adolescence, a first full-term pregnancy at an early age following exposure may be protective against radiation-related risk.

引用

页码：167 / 176

页数：10

共 33 条

[1]

Land C.E., Hayakawa N., Machado S., Et al., A case-control interview study of breast cancer among Japanese A-bomb survivors. I. Main effects, Cancer Causes Control, 5, pp. 157-65, (1994)

[2]

Wanebo C.K., Johnson K.G., Sato K., Thorslund T.W., Breast cancer after exposure to the atomic bombings of Hiroshima and Nagasaki, N Engl J Med, 279, pp. 667-71, (1968)

[3]

McGregor D.H., Land C.E., Choi K., Et al., Breast cancer incidence among atomic bomb survivors, Hiroshima and Nagasaki, 1950–1969, JNCI, 59, pp. 799-811, (1977)

[4]

Tokunaga M., Norman J.E., Asano M., Et al., Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950–74, JNCI, 62, pp. 1347-59, (1979)

[5]

Tokunaga M., Land C.E., Yamamoto T., Et al., Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950–1980, Radiat Res, 112, pp. 243-72, (1987)

[6]

Mole R.H., The sensitivity of the human breast to cancer induction by ionizing radiation, Br J Radiol, 51, pp. 401-5, (1978)

[7]

Land C.E., Tokunaga M., Tokuoka S., Nakamura N., Early-onset breast cancer among atomic bomb survivors: Evidence of a radiation-susceptible subgroup?, Lancet, 342, (1993)

[8]

Land C.E., Boice J.D., Shore R.E., Norman J.E., Tokunaga M., Breast cancer risk from low-dose exposures to ionizing radiation: Results of parallel analysis of three exposed populations of women, JNCI, 65, pp. 353-76, (1980)

[9]

Land C.E., Tokunaga M., Tokuoka S., Studies of breast cancer risk among atomic bomb survivors (and discussion following), The Future of Human Radiation Research, pp. 49-60, (1991)

[10]

MacMahon B., Cole P., Brown J., Etiology of human breast cancer: A review, JNCI, 50, pp. 21-42, (1973)

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