A CASE-CONTROL INTERVIEW STUDY OF BREAST-CANCER AMONG JAPANESE A-BOMB SURVIVORS .2. INTERACTIONS WITH RADIATION-DOSE

被引：65

作者：

LAND, CE

HAYAKAWA, N

MACHADO, SG

YAMADA, Y

PIKE, MC

AKIBA, S

TOKUNAGA, M

机构：

[1] Radiation Epidemiology Branch, National Cancer Institute, Bethesda, 20852, MD, 6130 Rockville Pike

[2] the Radiation Effects Research Foundation, Hiroshima and Nagasaki

[3] the Research Institute for Nuclear Medicine and Biology, Hiroshima University, Hiroshima

[4] the Food and Drug Administration, Rockville, MD

[5] Department of Community Medicine, University of Southern California, Los Angeles, CA

[6] Kagoshima City Hospital, Kagoshima

来源：

CANCER CAUSES & CONTROL | 1994年 / 5卷 / 02期

关键词：

A-BOMB SURVIVORS; BREAST CANCER; IONIZING RADIATION; JAPAN; REPRODUCTIVE HISTORY;

D O I：

10.1007/BF01830263

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three breast cancer risk factors were evaluated in terms of their interactions with radiation dose in a case-control interview study of Japanese A-bomb survivors. Cases and controls were matched on age at the time of the bombings and radiation dose, and dose-related risk was estimated from cohort rather than case-control data. Each factor-age at first full-term pregnancy, number of deliveries, and cumulative lactation period summed over births-conformed reasonably well to a multiplicative interaction model with radiation dose (the additive interactive model, in which the absolute excess risk associated with a factor is assumed to be independent of radiation dose, was rejected). An important implication of the finding is that early age at first full-term pregnancy, multiple births, and lengthy cumulative lactation are all protective against radiation-related, as well as baseline, breast cancer. Analyses by age at exposure to radiation suggest that, among women exposed to radiation in childhood or adolescence, a first full-term pregnancy at an early age following exposure may be protective against radiation-related risk.

引用

页码：167 / 176

页数：10

共 33 条

[11]

Henderson B.E., Pike M.C., Gray G.E., The epidemiology of breast cancer, Breast Cancer, pp. 1-25, (1981)

[12]

Kelsey J.L., Horn-Ross P.L., Breast cancer: magnitude of the problem and descriptive epidemiology, Epidemiol Rev, 15, pp. 7-16, (1993)

[13]

Kelsey J.L., Gammon M.D., John E.M., Reproductive factors and breast cancer, Epidemiol Rev, 15, pp. 36-47, (1993)

[14]

Ziegler R.G., Hoover R.N., Pike M.C., Et al., Migration patterns and breast cancer risk in Asian-American women, JNCI, 22, pp. 1819-27, (1993)

[15]

Land C.L., A Nested Case-control Approach to Interactions between Radiation Dose and Other Factors as Causes of Cancer, (1990)

[16]

Beebe G.W., Usagawa M., The Major ABCC Samples, (1968)

[17]

Shimizu Y., Kato H., Schull W.J., Studies of the mortality of A-bomb survivors. 9. Mortality, 1950–1985: Part 2. Cancer mortality based on the recently revised doses (DS86), Radiat Res, 121, pp. 120-41, (1988)

[18]

Milton R.C., Shohoji T., Tentative 1965 Radiation Dose (T65D) Estimation for Atomic Bomb Survivors, Hiroshima-Nagasaki, (1968)

[19]

Kerr G.D., Organ dose estimates for the Japanese atomic bomb survivors, Health Phys, 37, pp. 487-508, (1979)

[20]

U.S. Joint Reassessment of Atomic Bomb Radiation Dosimetry in Hiroshima and Nagasaki—Final Report, Vol. 1, (1987)

← 1 2 3 4 →