COUGH RECEPTOR SENSITIVITY AND BRONCHIAL RESPONSIVENESS IN PATIENTS WITH ONLY CHRONIC NONPRODUCTIVE COUGH - IN VIEW OF EFFECT OF BRONCHODILATOR THERAPY

被引：74

作者：

FUJIMURA, M

KAMIO, Y

HASHIMOTO, T

MATSUDA, T

机构：

[1] The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, 920

[2] Division of Pulmonary Function, The Central Laboratory Kanazawa University Hospital, Kanazawa, 920

[3] Department of Laboratory Medicine, Kanazawa University School of Medicine, Kanazawa, 920

来源：

JOURNAL OF ASTHMA | 1994年 / 31卷 / 06期

关键词：

D O I：

10.3109/02770909409089488

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Twenty-two patients with only chronic nonproductive cough lasting for more than 2 months were prospectively examined to determine whether airway cough receptor sensitivity and bronchial responsiveness relate to the efficacy of bronchodilator therapy on the cough. Clenbuterol (10 mu g, 4 times a day for 1 week) was effective on the cough in 10 patients (group 2) but not in the other 12 patients (group 1). Cough threshold to inhaled capsaicin was significantly less in group 1 than in group 2 at the first visit but not after the therapy when the cough stopped. Bronchial responsiveness to methacholine (PC20-FEV(1)) was not heightened in group 1, while that in group 2 was hyperreactive. These findings suggest that nonproductive cough is elicited based on two different mechanisms: (1) heightened airway cough receptor sensitivity in bronchodilator-resistant cough and (2) bronchoconstriction in bronchodilator-responsive cough such as cough-variant asthma.

引用

页码：463 / 472

页数：10

共 28 条

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