LIPASE YS-CATALYZED ACYLATION OF ALCOHOLS - A PREDICTIVE ACTIVE-SITE MODEL FOR LIPASE YS TO IDENTIFY WHICH ENANTIOMER OF A PRIMARY OR A SECONDARY ALCOHOL REACTS FASTER IN THIS ACYLATION

被引:49
作者
NAEMURA, K
FUKUDA, R
KONISHI, M
HIROSE, K
TOBE, Y
机构
[1] Department of Chemistry, Faculty of Engineering Science, Osaka University, Toyonaka
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 10期
关键词
D O I
10.1039/p19940001253
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Primary alcohols having a hydroxymethyl group at an S chiral centre and secondary alcohols with an R configuration are preferentially acylated to give the corresponding acetates by lipase YS-catalysed acylation in diisopropyl ether; a predictive cubic-spaced active site model for lipase YS is proposed for identifying which enantiomer of a primary or a secondary alcohol reacts faster in this acylation.
引用
收藏
页码:1253 / 1256
页数:4
相关论文
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