LIPASE YS-CATALYZED ACYLATION OF ALCOHOLS - A PREDICTIVE ACTIVE-SITE MODEL FOR LIPASE YS TO IDENTIFY WHICH ENANTIOMER OF A PRIMARY OR A SECONDARY ALCOHOL REACTS FASTER IN THIS ACYLATION

被引：49

作者：

NAEMURA, K

FUKUDA, R

KONISHI, M

HIROSE, K

TOBE, Y

机构：

[1] Department of Chemistry, Faculty of Engineering Science, Osaka University, Toyonaka

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 10期

关键词：

D O I：

10.1039/p19940001253

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Primary alcohols having a hydroxymethyl group at an S chiral centre and secondary alcohols with an R configuration are preferentially acylated to give the corresponding acetates by lipase YS-catalysed acylation in diisopropyl ether; a predictive cubic-spaced active site model for lipase YS is proposed for identifying which enantiomer of a primary or a secondary alcohol reacts faster in this acylation.

引用

页码：1253 / 1256

页数：4

共 23 条

[1]

AKIYAMA A, 1987, CHEM BRIT, V23, P645

[2] ENANTIOSELECTIVE ESTERIFICATIONS OF UNSATURATED ALCOHOLS MEDIATED BY A LIPASE PREPARED FROM PSEUDOMONAS SP [J].